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On the morning of February 10, 2025, the Spobio Research Center was honored to welcome Mrs. Isabelle Ducellier, the former CEO of Biogaia, for a visit and consultation regarding the potential development of probiotic products for the international market. This meeting provided a valuable opportunity to share ANABIO R&D’s research advancements and receive expert insights from a leading specialist in the field.

The 60-minute exchange left a profound impression on Mrs. Isabelle Ducellier, owing to the outstanding research conducted by the R&D laboratory. The collaborations with prestigious institutions, including the Central Pediatric Hospital, Thai Binh University of Medicine and Pharmacy, and the National Institute of Nutrition, have contributed to documenting the tangible benefits of probiotics in supporting the treatment of respiratory, digestive, and various other health conditions.

During the meeting, the research team presented their flagship probiotic products: PregMom, KID, Dia30, Colon, Clausy, Navax, and X-secret. These products have demonstrated exceptional efficacy in clinical trials and have been featured in renowned scientific journals such as Nature Scientific Reports and ASM. Notable findings include:

LiveSpo Navax effectively alleviates symptoms of ARTI caused by RSV while reducing viral load, offering a simple, cost-effective treatment approach for viral infections in general.

LiveSpo Colon significantly improves symptoms of chronic intestinal inflammation, including colitis, diarrhea, and constipation, while enhancing inflammatory markers and quality of life after 30 days of treatment. These improvements have been documented through comparative colonoscopy images from before and after product use.

LiveSpo Clausy regulates inflammation through the Th17 mechanism and has shown particularly promising results in reducing the duration of prolonged diarrhea in children aged 3-24 months. This contributes to reducing antibiotic use, protecting gut microbiota, and promoting healthier growth in children.

LiveSpo X-secret effectively alleviates symptoms of STDs, reduces pathogenic bacterial load, and improves the vaginal microbiota.

LiveSpo DIA30 has demonstrated remarkable effectiveness in treating prolonged diarrhea in children by reducing inflammation and improving gut microbiota without requiring antibiotics.

LiveSpo KIDS and LiveSpo PREG-MOM effectively alleviate constipation and malnutrition in children while strengthening immune systems and restoring gut microbiota.

Significantly, all ANABIO probiotic products have proven safe, with no reported side effects in clinical studies. This evidence demonstrates the effectiveness of probiotics in reducing antibiotic treatment duration, aligning with ANABIO R&D’s overarching goal: “For a future without antibiotics.”

In addition to the achievements, Mrs. Isabelle Ducellier was particularly impressed by the community-focused vision that ANABIO’s founder has instilled in every member of the research team. The unity, relentless creativity, and determination to overcome challenges in completing each study clearly reflect their shared goal: to benefit public health, with a particular focus on children’s health.

This meeting not only provided an opportunity for the Spobio Research Center to showcase its scientific accomplishments to an international expert but also served as a testament to ANABIO R&D’s commitment to LiveSpo Pharma’s vision: “For a future without antibiotics.”

Here are some pictures from the tour

The Spobiotic Research Center (Spobio Center), ANABIO R&D participated in the Dental Exhibition & Congress 2024 (VNU DEC 2024), held on November 22–23, 2024, at Vietnam National University, Hanoi. With the theme “Education and Practice in Odonto-Stomatology”,  VNU DEC 2024 brought together hundreds of leading dental experts from Vietnam and around the world. The conference was organized in collaboration with Operation Smile, US, to commemorate 35 years of its operations in Vietnam.

Representing the Spobio Center, three staff members, along with the LiveSpo Pharma, actively presented innovative probiotic spore products. Highlights included LiveSpo Navax – the world’s first respiratory probiotic – and LiveSpo^® Smile CARE – a pioneering probiotic solution for comprehensive oral care.

With Bacillus spores as its primary component, LiveSpo^® Smile CARE offers a holistic approach to oral health. The product not only cleanses the oral cavity, prevents cavities and gingivitis, and inhibits bacterial plaque formation – resulting in stronger teeth – but also helps balance the natural oral microbiome. This is recognized as a significant advancement, paving the way for modern dentistry without relying on antibiotics.

The LiveSpo Pharma booth at VNU DEC 2024 attracted considerable attention and received positive feedback from dental professionals. These responses not only reinforced the company’s pioneering position in applying probiotic spore technology but also underscored its commitment to improving community health, striving for “a future without antibiotics”.

From October 31st to November 2nd, 2024, the Spobiotic Research Center, ANABIO R&D, participated in the 25th National Pediatrics Conference in Hue City entiled “From Science to Policy and Practice.” The conference is a prestigious scientific forum, gathering leading experts from Vietnam and abroad to share the latest advancements in pediatrics.

At the conference, Dr. Dang Thuy Ha, MD, PhD, Deputy Head of the Gastroenterology Department at the National Children’s Hospital, presented the report “Characteristics of Gut Microbiota and Treatment Outcomes for Persistent Diarrhea at the National Children’s Hospital.” This research was conducted in collaboration between the doctors of the National Children’s Hospital and the Spobiotic Research Center, ANABIO R&D. The report highlighted positive results in shortening treatment duration and increasing the effectiveness of managing persistent diarrhea in children by combining conventional treatments with water-based probiotic Bacillus spore products such as LiveSpo CLAUSY (Bacillus clausii, 2 billion CFU/5 mL) and LiveSpo DIA30 (Bacillus subtilis, Bacillus clausii, Bacillus coagulans, 5 billion CFU/5 mL). These products have been recognized as promising solutions in treating prolonged diarrhea, contributing to reduced antibiotic use in children. Findings from the study were published in Nature Scientific Reports in March 2024, providing further scientific support for optimizing treatment protocols for children with prolonged diarrhea.

The conference also featured participation from numerous health administrators and leaders from healthcare facilities across the country, offering an opportunity for a comprehensive evaluation of issues in pediatrics to develop and refine appropriate health policies. Contributions at the conference not only aim to enhance the quality of child healthcare but also lay the foundation for sustainable development of Vietnam’s healthcare sector in pediatrics. This information serves as valuable updates for scientists of the Spobiotic Research Center, ANABIO R&D, to generate ideas for probiotic product development, aligned with the mission of “a future without antibiotics.”

Recently, the Spobiotic Research Center collaborated with Hanoi Medical University to conduct the study titled “Efficacy of Saline Solution and Probiotic Products in Preventing Upper Respiratory Infections in Children Aged 2 to 6 in Son Tay Town, Hanoi, 2024.” This study, led by Assoc. Prof. Dr. Nguyen Thi Hoai Thu, was reviewed and accepted by the Institute for Preventive Medicine and Public Health, Hanoi Medical University. This collaboration marks a significant advancement in probiotic research, aiming to support respiratory disease prevention in young children and reduce antibiotic dependency, especially in the field of preventive healthcare

This is the first study in the world to demonstrate the safety and superior effectiveness of nasal spray probiotics containing Bacillus spores (LiveSpo^® NAVAX and LiveSpo^® NAVAX KIDS) in preventing and reducing the recurrence of upper respiratory tract infections in children. Clinical trial results revealed that after 14 and 28 days of use, LiveSpo^® NAVAX and LiveSpo^® NAVAX KIDS effectively reduced typical respiratory symptoms-such as runny nose, sinusitis, hoarseness, pharyngitis, and tonsillitis compared to baseline and in comparison, with saline solution.

A key highlight of this research is the outstanding ability of LiveSpo^® NAVAX and LiveSpo^® NAVAX KIDS to prevent pathogenic viruses and bacteria, significantly reducing infection rates and the risk of viral infections such as including RSV, influenza, and rhinovirus, compared to physiological saline. Additionally, probiotics have shown the ability to regulate immunity, strengthening respiratory defenses and significantly reduce the rate of children needing to miss school or take antibiotics, anti-inflammatory drugs, etc.

The study received an “Excellent”  by the evaluation committee due to its high applicability and safety for children. LiveSpo^® NAVAX promises to become a potential solution in preventing respiratory tract infections, especially during the changing seasons, helping to minimize dependence on antibiotics in the treatment of respiratory infections in children.

Four staff members from the Spobio Research Center, ANABIO R&D Ltd, represented the company at the 27th National Scientific Conference on Otolaryngology & Head and Neck Surgery, held from November 1^st to 3^rd, 2024, in Ninh Binh City, Ninh Binh Province. This prestigious event attracted numerous leading experts, doctors, and pharmacists from both domestic and international communities to discuss, share, and update each other on prominent advancements in the field of Otolaryngology.

At the conference, Assoc. Prof. Dr. MD. Pham Tran Anh, who works at the Central Otolaryngology Hospital and is also a lecturer at the Department of Otolaryngology, Hanoi Medical University, presented a report titled “Effectiveness of Nasal-spraying Bacillus Spores in Preventing Respiratory Tract Infections in Children: Results from the Community Intervention Study 2023-2024.” This report is part of a scientific project in collaboration with the Institute of Preventive Medicine and Public Health, Hanoi Medical University, and the Spobio Research Center, ANABIO R&D Ltd. The report highlighted the safety and superior efficacy of the LiveSpo^® NAVAX and LiveSpo^® NAVAX KIDS products in protecting children’s respiratory health. Specifically, LiveSpo^® NAVAX significantly reduced the incidence of typical respiratory infection symptoms such as runny nose, sinusitis, hoarseness, sore throat, and tonsillitis by up to 60% after 14 and 28 days of use. Furthermore, the rate of children missing school due to illness and the use of antibiotics and anti-inflammatory medications also showed a significant decrease. Notably, LiveSpo^® NAVAX and LiveSpo^® NAVAX KIDS helped reduce the rate of bacterial infections by up to 70% and decreased the risk of viral infections such as RSV and influenza by more than 11 folds, showing superior results compared to the use of saline solution.

The study results present new opportunities for using Bacillus spores to prevent respiratory diseases in children, especially during seasonal changes. The report by Assoc. Prof. Dr. MD. Pham Tran Anh received considerable attention and high praise from leading experts and doctors in the field of Otolaryngology.

Outside of the report sessions, the booth showcasing LiveSpo^® NAVAX and LiveSpo^® NAVAX KIDS also drew considerable attention from experts and doctors. Delegates expressed special interest in the effectiveness of these products in preventing respiratory diseases in children.